Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0350794
PubChem CID
Molecular Formula
C16H17ClN6O2
Molecular Weight
360.805 g/mol
Synonyms/Alias
[CM-TPMF; (-)-CM-TPMF; GTPL9314; N-{7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1;2;4]triazolo[1;5-a]pyrimidin-2-yl}-N-methoxymethanimidamide; N-(7-(1-(4-Chloro-2-methylphenoxy)ethyl)(1;2;4)triazolo[1;5-a]...
InChI Key
OZWWQEQUDKBSCF-UHFFFAOYSA-N
InChI
InChI=1S/C16H17ClN6O2/c1-10-8-12(17)4-5-14(10)25-11(2)13-6-7-18-16-21-15(22-23(13)16)19-9-20-24-3/h4...
IUPAC Name
N-[7-[1-(4-chloro-2-methylphenoxy)ethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]-N-methoxymethanimidamide
CAS Number
477865-59-1

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

42 44 0 0 0 0 0 0 0 0999 V2000
-4.2864 -1.3704 1.3274 C 0 0 0 0 0 0 0 0 0 0 0 0
-4.2113 0.1133 1.1032 C 0 0 0 0 0 0 0 0 0 0 0 0
-3.1138 0.670...

Experimental Data

Activity Data

Target Ion Channel
Small conductance Calcium activated potassium channel protein 1
Uniprot Accession Number
Function
Activator
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 24 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.2
Holding Potential
−80 to 80 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)

Binding Information

Binding Site
Not specified
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
25
Rotatable Bonds
6
logP
3.0369
Complexity
94.3107
TPSA (Ų)
85.93
H-Bond Donors
1
H-Bond Acceptors
7
Ring Count
3
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